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V\u00e0o gi\u1eefa n\u0103m 2025, COVID-19 \u0111\u00e3 b\u01b0\u1edbc v\u00e0o giai \u0111o\u1ea1n l\u01b0u h\u00e0nh v\u1edbi s\u1ef1 ti\u1ebfn h\u00f3a li\u00ean t\u1ee5c c\u1ee7a virus v\u00e0 mi\u1ec5n d\u1ecbch kh\u00f4ng \u0111\u1ed3ng \u0111\u1ec1u gi\u1eefa c\u00e1c qu\u1ea7n th\u1ec3. SARS-CoV-2 ti\u1ebfp t\u1ee5c \u0111\u1ed9t bi\u1ebfn, ch\u1ee7 y\u1ebfu \u1edf protein gai, cho ph\u00e9p n\u00f3 b\u00e1m ch\u1eb7t h\u01a1n v\u00e0o c\u00e1c t\u1ebf b\u00e0o ng\u01b0\u1eddi v\u00e0 tho\u00e1t kh\u1ecfi h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch. Kh\u1ea3 n\u0103ng th\u00edch \u1ee9ng n\u00e0y \u0111\u00e3 t\u1ea1o ra c\u00e1c bi\u1ebfn th\u1ec3 nh\u01b0 NB.1.8.1, LP.8.1 v\u00e0 XFG, l\u00e2y lan nhanh ch\u00f3ng nh\u1edd kh\u1ea3 n\u0103ng l\u00e2y truy\u1ec1n t\u0103ng cao v\u00e0 kh\u00e1ng kh\u00e1ng th\u1ec3 hi\u1ec7n c\u00f3.<\/p>\n
T\u1eeb cu\u1ed1i n\u0103m 2024 \u0111\u1ebfn gi\u1eefa n\u0103m 2025, d\u1eef li\u1ec7u d\u1ecbch t\u1ec5 cho th\u1ea5y s\u1ef1 bi\u1ebfn \u0111\u1ed9ng \u0111\u00e1ng k\u1ec3 v\u1ec1 s\u1ed1 ca m\u1eafc, v\u1edbi c\u00e1c \u0111\u1ee3t nh\u1eadp vi\u1ec7n t\u0103ng \u0111\u1ed9t bi\u1ebfn theo v\u00f9ng v\u00e0 t\u1ef7 l\u1ec7 x\u00e9t nghi\u1ec7m d\u01b0\u01a1ng t\u00ednh gia t\u0103ng. Ch\u1eb3ng h\u1ea1n, t\u1ef7 l\u1ec7 d\u01b0\u01a1ng t\u00ednh v\u1edbi virus \u0111\u00e3 t\u0103ng t\u1eeb 2% l\u00ean 11% gi\u1eefa th\u00e1ng 2 v\u00e0 th\u00e1ng 5 n\u0103m 2025, m\u1ee9c cao nh\u1ea5t k\u1ec3 t\u1eeb m\u00f9a h\u00e8 n\u0103m 2024. Ch\u00e2u M\u1ef9, Ch\u00e2u \u00c2u v\u00e0 \u0110\u00f4ng Nam \u00c1 ghi nh\u1eadn s\u1ef1 gia t\u0103ng \u0111\u00e1ng k\u1ec3 nh\u1ea5t, ph\u1ea3n \u00e1nh s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 mi\u1ec5n d\u1ecbch c\u1ed9ng \u0111\u1ed3ng, s\u1ef1 l\u01b0u h\u00e0nh c\u1ee7a c\u00e1c bi\u1ebfn th\u1ec3 v\u00e0 n\u0103ng l\u1ef1c gi\u00e1m s\u00e1t.<\/p>\n
C\u00e1c bi\u1ebfn th\u1ec3 th\u1ed1ng tr\u1ecb \u0111\u00e3 thay \u0111\u1ed5i nhanh ch\u00f3ng trong giai \u0111o\u1ea1n n\u00e0y. V\u00e0o th\u00e1ng 1 n\u0103m 2025, XEC v\u00e0 LP.8.1 chi\u1ebfm g\u1ea7n 50% c\u00e1c ch\u1ee7ng \u0111\u01b0\u1ee3c gi\u00e1m s\u00e1t, trong khi JN.1 v\u00e0 KP.3.1.1 suy gi\u1ea3m. \u0110\u1ebfn th\u00e1ng 3, LP.8.1 tr\u1edf th\u00e0nh bi\u1ebfn th\u1ec3 ch\u1ee7 \u0111\u1ea1o, tr\u01b0\u1edbc khi b\u1ecb v\u01b0\u1ee3t qua v\u00e0o th\u00e1ng 6 b\u1edfi NB.1.8.1 v\u00e0 XFG, hai bi\u1ebfn th\u1ec3 sau c\u00f9ng chi\u1ebfm h\u01a1n 30% m\u1ed7i lo\u1ea1i. Nh\u1eefng bi\u1ebfn th\u1ec3 n\u00e0y chia s\u1ebb c\u00e1c \u0111\u1ed9t bi\u1ebfn quan tr\u1ecdng \u1edf protein gai, ch\u1eb3ng h\u1ea1n nh\u01b0 F456L ho\u1eb7c Q493E, gi\u00fap ch\u00fang c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng n\u00e9 tr\u00e1nh kh\u00e1ng th\u1ec3 trung h\u00f2a. Ch\u1eb3ng h\u1ea1n, XFG k\u1ebft h\u1ee3p c\u00e1c s\u1eeda \u0111\u1ed5i c\u1ee7ng c\u1ed1 c\u1ea3 kh\u1ea3 n\u0103ng tho\u00e1t mi\u1ec5n d\u1ecbch l\u1eabn s\u1ef1 \u1ed5n \u0111\u1ecbnh c\u1ee7a virus, gi\u1ea3i th\u00edch cho s\u1ef1 l\u00e2y lan to\u00e0n c\u1ea7u nhanh ch\u00f3ng c\u1ee7a n\u00f3.<\/p>\n
V\u1eafc-xin v\u1eabn l\u00e0 c\u00f4ng c\u1ee5 thi\u1ebft y\u1ebfu \u0111\u1ec3 h\u1ea1n ch\u1ebf m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a b\u1ec7nh. C\u00e1c c\u00f4ng th\u1ee9c v\u1eafc-xin d\u1ef1a tr\u00ean c\u00f4ng ngh\u1ec7 mRNA, ch\u1eb3ng h\u1ea1n nh\u01b0 nh\u1eefng lo\u1ea1i \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh cho c\u00e1c bi\u1ebfn th\u1ec3 JN.1 v\u00e0 KP.2, cho th\u1ea5y ph\u1ea3n \u1ee9ng trung h\u00f2a m\u1ea1nh m\u1ebd ch\u1ed1ng l\u1ea1i c\u00e1c ch\u1ee7ng l\u01b0u h\u00e0nh v\u00e0o n\u0103m 2025. Tuy nhi\u00ean, hi\u1ec7u qu\u1ea3 c\u1ee7a ch\u00fang gi\u1ea3m d\u1ea7n theo th\u1eddi gian, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf ng\u01b0\u1eddi cao tu\u1ed5i. V\u1eafc-xin vector virus ho\u1eb7c v\u1eafc-xin \u0111\u01a1n v\u1ecb protein, m\u1eb7c d\u00f9 ban \u0111\u1ea7u k\u00e9m hi\u1ec7u qu\u1ea3 h\u01a1n, l\u1ea1i cung c\u1ea5p s\u1ef1 b\u1ea3o v\u1ec7 l\u00e2u d\u00e0i nh\u1edd ph\u1ea3n \u1ee9ng t\u1ebf b\u00e0o v\u1eefng ch\u1eafc, \u0111\u1eb7c bi\u1ec7t l\u00e0 th\u00f4ng qua lympho T. Nh\u1eefng t\u1ebf b\u00e0o n\u00e0y, nh\u1eafm tr\u1ef1c ti\u1ebfp v\u00e0o c\u00e1c t\u1ebf b\u00e0o b\u1ecb nhi\u1ec5m, \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong tr\u00ed nh\u1edb mi\u1ec5n d\u1ecbch d\u00e0i h\u1ea1n.<\/p>\n
Chi\u1ebfn l\u01b0\u1ee3c ti\u00eam nh\u1eafc, \u0111\u1eb7c bi\u1ec7t l\u00e0 v\u1edbi c\u00e1c v\u1eafc-xin k\u1ebft h\u1ee3p nhi\u1ec1u c\u00f4ng ngh\u1ec7, ch\u1ee9ng t\u1ecf hi\u1ec7u qu\u1ea3 trong vi\u1ec7c duy tr\u00ec mi\u1ec5n d\u1ecbch r\u1ed9ng r\u00e3i v\u00e0 b\u1ec1n v\u1eefng. Ch\u1eb3ng h\u1ea1n, li\u1ec1u nh\u1eafc b\u1eb1ng v\u1eafc-xin mRNA sau li\u1ec1u c\u01a1 b\u1ea3n b\u1eb1ng vector virus c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch, c\u1ea3 v\u1ec1 kh\u00e1ng th\u1ec3 l\u1eabn t\u1ebf b\u00e0o T. \u0110i\u1ec1u n\u00e0y gi\u00fap c\u01a1 th\u1ec3 ch\u1ed1ng ch\u1ecdi t\u1ed1t h\u01a1n v\u1edbi c\u00e1c bi\u1ebfn th\u1ec3 m\u1edbi, ngay c\u1ea3 khi kh\u1ea3 n\u0103ng tho\u00e1t kh\u1ecfi h\u1ec7 mi\u1ec5n d\u1ecbch hi\u1ec7n c\u00f3 c\u1ee7a ch\u00fang ti\u1ebfp t\u1ee5c gia t\u0103ng.<\/p>\n
Gi\u00e1m s\u00e1t h\u1ec7 gene to\u00e0n c\u1ea7u, v\u1edbi h\u01a1n 17 tri\u1ec7u tr\u00ecnh t\u1ef1 \u0111\u01b0\u1ee3c chia s\u1ebb, \u0111\u00e3 cho ph\u00e9p theo d\u00f5i nh\u1eefng ti\u1ebfn h\u00f3a n\u00e0y v\u00e0 \u0111i\u1ec1u ch\u1ec9nh c\u00e1c bi\u1ec7n ph\u00e1p y t\u1ebf. Tuy nhi\u00ean, s\u1ef1 ch\u00eanh l\u1ec7ch v\u1ec1 ti\u1ebfp c\u1eadn ch\u0103m s\u00f3c y t\u1ebf v\u00e0 v\u1eafc-xin gi\u1eefa c\u00e1c v\u00f9ng, c\u0169ng nh\u01b0 s\u1ef1 suy gi\u1ea3m d\u1ea7n mi\u1ec5n d\u1ecbch, nh\u1ea5n m\u1ea1nh s\u1ef1 c\u1ea7n thi\u1ebft ph\u1ea3i c\u1ee7ng c\u1ed1 c\u01a1 s\u1edf h\u1ea1 t\u1ea7ng y t\u1ebf v\u00e0 ph\u00e1t tri\u1ec3n c\u00e1c th\u1ebf h\u1ec7 v\u1eafc-xin m\u1edbi. Nh\u1eefng v\u1eafc-xin m\u1edbi n\u00e0y nh\u1eafm \u0111\u1ebfn nhi\u1ec1u kh\u00e1ng nguy\u00ean \u0111\u1ec3 cung c\u1ea5p s\u1ef1 b\u1ea3o v\u1ec7 r\u1ed9ng r\u00e3i v\u00e0 b\u1ec1n v\u1eefng h\u01a1n, \u0111\u1ed3ng th\u1eddi k\u00edch th\u00edch ph\u1ea3n \u1ee9ng c\u1ee7a lympho T c\u00f3 kh\u1ea3 n\u0103ng trung h\u00f2a c\u00e1c bi\u1ebfn th\u1ec3 kh\u00e1c nhau.<\/p>\n
Nh\u1eefng quan s\u00e1t g\u1ea7n \u0111\u00e2y x\u00e1c nh\u1eadn r\u1eb1ng virus kh\u00f4ng ng\u1eebng t\u1ed1i \u01b0u h\u00f3a c\u01a1 ch\u1ebf tho\u00e1t mi\u1ec5n d\u1ecbch, trong khi c\u00e1c v\u1eafc-xin hi\u1ec7n t\u1ea1i, m\u1eb7c d\u00f9 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1ea3i ti\u1ebfn, v\u1eabn kh\u00f3 duy tr\u00ec s\u1ef1 b\u1ea3o v\u1ec7 ho\u00e0n to\u00e0n trong d\u00e0i h\u1ea1n. S\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a nh\u1eefng y\u1ebfu t\u1ed1 n\u00e0y khi\u1ebfn vi\u1ec7c ti\u1ebfp c\u1eadn to\u00e0n di\u1ec7n tr\u1edf n\u00ean c\u1ea5p thi\u1ebft, k\u1ebft h\u1ee3p \u0111\u1ed5i m\u1edbi khoa h\u1ecdc v\u00e0 h\u1ee3p t\u00e1c qu\u1ed1c t\u1ebf \u0111\u1ec3 d\u1ef1 \u0111o\u00e1n c\u00e1c l\u00e0n s\u00f3ng trong t\u01b0\u01a1ng lai v\u00e0 gi\u1ea3m thi\u1ec3u t\u00e1c \u0111\u1ed9ng c\u1ee7a d\u1ecbch b\u1ec7nh.<\/p>\n
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DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1186\/s12982-026-01657-z<\/a><\/p>\n Titre\u00a0:<\/strong> SARS-CoV-2 variant dynamics and COVID-19 vaccine effectiveness during global epidemiological changes in mid-2025<\/p>\n Revue : <\/strong> Discover Public Health<\/p>\n \u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n Auteurs : <\/strong> Risha Haldar; Prolay Halder; Bhaskar Mahanayak<\/p>\n","protected":false},"excerpt":{"rendered":" “`html Virus COVID-19 ti\u1ebfn h\u00f3a v\u00e0 v\u1eafc-xin th\u00edch \u1ee9ng v\u00e0o n\u0103m 2025 V\u00e0o gi\u1eefa n\u0103m 2025, COVID-19 \u0111\u00e3 b\u01b0\u1edbc v\u00e0o giai \u0111o\u1ea1n l\u01b0u h\u00e0nh v\u1edbi s\u1ef1 ti\u1ebfn h\u00f3a li\u00ean t\u1ee5c c\u1ee7a virus v\u00e0 mi\u1ec5n d\u1ecbch kh\u00f4ng \u0111\u1ed3ng \u0111\u1ec1u gi\u1eefa c\u00e1c qu\u1ea7n th\u1ec3. SARS-CoV-2 ti\u1ebfp t\u1ee5c \u0111\u1ed9t bi\u1ebfn, ch\u1ee7 y\u1ebfu \u1edf protein gai, cho ph\u00e9p n\u00f3… Continue reading Virus COVID-19 ti\u1ebfn h\u00f3a v\u00e0 v\u1eafc-xin th\u00edch \u1ee9ng v\u00e0o n\u0103m 2025<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,4],"tags":[],"class_list":["post-21","post","type-post","status-publish","format-standard","hentry","category-khoa-hoc-cong-nghe","category-suc-khoe","entry"],"_links":{"self":[{"href":"https:\/\/theinternationaljournal.media\/vi\/wp-json\/wp\/v2\/posts\/21","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/theinternationaljournal.media\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/theinternationaljournal.media\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/theinternationaljournal.media\/vi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/theinternationaljournal.media\/vi\/wp-json\/wp\/v2\/comments?post=21"}],"version-history":[{"count":1,"href":"https:\/\/theinternationaljournal.media\/vi\/wp-json\/wp\/v2\/posts\/21\/revisions"}],"predecessor-version":[{"id":22,"href":"https:\/\/theinternationaljournal.media\/vi\/wp-json\/wp\/v2\/posts\/21\/revisions\/22"}],"wp:attachment":[{"href":"https:\/\/theinternationaljournal.media\/vi\/wp-json\/wp\/v2\/media?parent=21"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/theinternationaljournal.media\/vi\/wp-json\/wp\/v2\/categories?post=21"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/theinternationaljournal.media\/vi\/wp-json\/wp\/v2\/tags?post=21"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}